Industrial Symbiosis can be considered as a strategy for sharing and valorising resources  including materials, energy, water, assets, expertise, logistics, capacity, equipments) between companies, so that a non-product produced by an industry can be used as an input by someone else (synergy). ENEA (Italian National Agency for New Technologies, Energy and Sustainable Economic Development) in 2011 started the project “Ecoinnovation Sicily” for the development of the first Italian Industrial Symbiosis Platform (Platform) to be implemented in Sicilia Region (among many other issues). The Platform addressed, in particularly, to small and medium enterprises (SMEs) and other local stakeholders, offers many other tools, beyond the industrial symbiosis, useful for supporting industries for the eco-innovation. This paper explains the methodology for the identification of potential synergies and the pathways for their actual implementation, with the specific focus on streams coming from agroindustry.