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In vivo characterization of Zirconia Toughened Alumina material: A comparative animal study

TitleIn vivo characterization of Zirconia Toughened Alumina material: A comparative animal study
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2010
AuthorsMaccauro, G., Cittadini A., Magnani G., Sangiorgi S., Muratori F., Manicone P.F., P. Iommetti Rossi, Marotta D., Chierichini A., Raffaelli L., and Sgambato A.
JournalInternational Journal of Immunopathology and Pharmacology
Volume23
Pagination841-846
ISSN03946320
Keywordsaluminum oxide, animal experiment, animal tissue, Animals, article, biocompatibility, Biocompatible Materials, biomaterial, Bone and Bones, carcinogenicity, Ceramics, comparative study, dental device, dental surgery, Female, immunohistochemistry, implant, in vivo study, male, Materials testing, nonhuman, orthopedic surgery, priority journal, Prostheses and Implants, rabbit, Rabbits, Surface properties, tissue reaction, unclassified drug, Zirconia toughened alumina, zirconium, zirconium oxide
Abstract

The development of a new chromia-doped Zirconia Toughened Alumina (ZTA) material was previously reported as displaying mechanical properties suitable for implants with load bearing applications, such as orthopaedic and dental implants. This type of biomaterial is expected to be in contact with living tissues for a long period of time and its long-term toxicity must be carefully evaluated. In this study the suitability of this ZTA material as a candidate biomaterial for orthopaedic implants and dental devices was further investigated in vivo in comparison to alumina and zirconia, which are currently used in orthopaedic and dental surgery. Cylinders of the materials were implanted in vivo in white rabbits, and local and systemic tissue reactions were analyzed at different time intervals after surgery. Radiologic examinations displayed the absence of radiolucence around cylinders and no signs of implant loosening up to twelve months. No tumours developed in the animals either locally (at the site of implantation), or systemically in the peripheral organs. The results obtained suggest that this new ZTA material does not display any long term pathogenic effect in vivo. These findings extend our previous observations on the biocompatibility and the absence of any long-term carcinogenic effect in vitro of this material which displays interesting properties for biomedical applications. In conclusion, we report the in vivo characterization of a new chromia-doped ZTA material and confirm its suitability as a candidate biomaterial for orthopaedic implants and dental devices since it does not give any local nor systemic toxicity even after a long period of time after implantation. Copyright © by BIOLIFE, s.a.s.

Notes

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-78149248119&partnerID=40&md5=5665b27996e185a92531f82a3721b469
Citation KeyMaccauro2010841