The interest in developing pesticides of natural origins has increased during recent years,because of the drawback of synthetic chemical pesticides, like impact on environment,toxicity to non target organisms including humans, resistance development in insect population. Furthermore, other considerations emerged, including low cost, renewable raw material, like wasting, interest for a possible individual use in urban area. In this paper attention was focused on products of neem tree, Azadiractha indica (A. Juss, 1830), and in particular on neem cake, the by-product obtained in the cold-pressed process of neem oil production. Actually neem cake marketed products are not used as pesticides, but mainly as fertilizers. Data on their compositions and insecticidal activity are lacking.Studies on marketed neem cake products made by HPTLC and HPLC analyses showed differences in their compositions, in particular on limonoids. Once determined limonoid contents in extracts of increasing polarity, these contents were related to larvicidal activity on Asian tiger mosquito, Aedes albopictus (Skuse, 1894). The aim of the reported studies is check the possibility of developing a new domestic insecticide using neem cake as raw material, in particular against biting mosquitos present in urban areas.