Sorry, you need to enable JavaScript to visit this website.

Do human lymphocytes exposed to the fallout of the Chernobyl accident exhibit an adaptive response? 1. Challenge with ionizing radiation

TitoloDo human lymphocytes exposed to the fallout of the Chernobyl accident exhibit an adaptive response? 1. Challenge with ionizing radiation
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione1995
AutoriPadovani, Laura Maria, Appolloni Massimo, Anzidei Patrizia, Tedeschi B., Caporossi D., Vernole P., and Mauro Francesco
RivistaMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume332
Paginazione33 - 38
Data di pubblicazione1995///
Parole chiaveAdaptive response, Chernobyl, Chromosome aberration, Ionizing radiation
Abstract

Several studies suggest that cells appear to become less susceptible to the induction of radiation damage, and in particular of chromosome and chromatid aberrations in short-term cultures of human lymphocytes, when a challenge exposure to ionizing radiation is preceded by a low ’adaptive’ dose. Contradictory results have been reported on the conditions under which the phenomenon can be evidenced. In the present work, circulating lymphocytes of 13 children contaminated from the fallout after the Chernobyl accident were tested for their capability to exhibit an adaptive response in experiments in which the challenge dose was administered to stimulated lymphocytes in the S-G, phase. Furthermore, the possible influence of 3-aminobenzamide, an inhibitor of poly(ADP-ribose) polymerase, was also investigated. Our results indicate that, at least in the instance of the end-point here used (chromosome and chromatid aberrations, the former resulting possibly from the Cs burden), human lymphocytes, chronically exposed to low doses from fallout, do not exhibit any decreased susceptibility to ionizing radiation. However, as reported in the accompanying paper, the same samples appear to show an ’adaptive’ response when exposed to a challenge treatment with bleomycin (B. Tedeschi et al., 1995, this issue).

Note

Cited By (since 1996): 10Export Date: 26 August 2010Source: Scopus

URLhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0028822789&partnerID=40&md5=24e2d824e455a6c3834d177a0f67625b
Citation Key459