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Alginate Microsponges as a Scaffold for Delivery of a Therapeutic Peptide against Rheumatoid Arthritis

TitoloAlginate Microsponges as a Scaffold for Delivery of a Therapeutic Peptide against Rheumatoid Arthritis
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2023
AutoriAriaudo, D., Cavalieri F., Rinaldi Antonio, Aguilera A., Lopez M., Perez H.G., Felipe A., M. Dominguez del Carmen, Ruiz O., Martinez G., and Venanzi M.
RivistaNanomaterials
Volume13
ISSN20794991
Abstract

The quest for biocompatible drug-delivery devices that could be able to open new administration routes is at the frontier of biomedical research. In this contribution, porous polysaccharide-based microsponges based on crosslinked alginate polymers were developed and characterized by optical spectroscopy and nanoscopic microscopy techniques. We show that macropores with a size distribution ranging from 50 to 120 nm enabled efficient loading and delivery of a therapeutic peptide (CIGB814), presently under a phase 3 clinical trial for the treatment of rheumatoid arthritis. Alginate microsponges showed 80% loading capacity and sustained peptide release over a few hours through a diffusional mechanism favored by partial erosion of the polymer scaffold. The edible and biocompatible nature of alginate polymers open promising perspectives for developing a new generation of polysaccharide-based carriers for the controlled delivery of peptide drugs, exploiting alternative routes with respect to intravenous administration. © 2023 by the authors.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85173801547&doi=10.3390%2fnano13192709&partnerID=40&md5=12998038a3b2d1ff67904c17d7db6466
DOI10.3390/nano13192709
Citation KeyAriaudo2023