The strategic management of supply chains, by ensuring closed-loop manufacturing processes and a constant reduction of industrial waste, is an essential pillar of sustainability. This is the pattern behind the, so-called, circular supply chains. The effective adoption of this paradigm demands the supply chains actors to establish robust integration and relationships, so that waste and by‐products of an industry or industrial process become the raw materials for others. This circular network is defined as industrial symbiosis. Starting from a background on this topic, this working paper explores the potential of blockchain as enabling technology of Industry 4.0 to disseminate industrial symbiosis practices within the modern industrial scenario. A preliminary two-step framework, i.e., conceptual and operative, is presented including insights and win–win synergies showing the potential of blockchain technology in supporting informative flows of industrial symbiosis. Preliminary field experiences are suggested, along with existing limitations and perspectives on future research. © The Author(s) 2024.

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